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KMID : 0385520140270010027
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Analytical Science & Technology
2014 Volume.27 No. 1 p.27 ~ p.33
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Preparation of cross-linked silk fibroin film by r-irradiation and their application as supports for human cell culture
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Park Hyean-Yeol
Choi Seong-Ho
Kim Yoon-Seob
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Abstract
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This study described about preparation of the cross-linked silk fibroin (SF) film by γ-irradiation of the casted SF film, which is fabricated from aqueous solution regenerated via fibers of cocoons and their application as supports for human cell culture. The properties of cross-linked SF film were evaluated by FTIR spectroscopy, contact angle, solubility to water, thermal analysis, surface area analyzer, and morphology via scanning electron microscopy (SEM). The cross-linked SF films were not dissolved in water and exhibited the rough surface morphology, large surface area, and good thermal properties. The human fibroblast cell (CCD- 986sk) and embryo kidney-ft cell were well growed on the surface of cross-linked SF film supports prepared by γ-irradiation. The cross-linked SF film prepared by γ-irradiation can be used as biomaterials for human cell culture.
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KEYWORD
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cross-linked silk fibroin film, r-Irradiation, human cell culture, human fibroblast cell, human embryo kidney-ft cell
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